Interactions: TFIIA binds directly to TBP and stabilizes its binding to DNA, perhaps through direct contacts of its own with the DNA. TFIIA binding does not preclude TFIIB binding or other components of the transcription complex. However, binding of TFIIA to TBP is mutually exclusive with binding of some negative regulatory proteins.
Features: Both subunits of TFIIA are extremely acidic.
Functions: The current wisdom is that TFIIA acts as an anti-repressor, stabilizing TFIID binding by blocking repressors of transcription that inhibit binding of other transcription factors or that remove TBP from the DNA. Activation of transcription may be dependent on this TFIIA function.
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