TFIIB

Protein composition: Single subunit. To date, all TFIIB proteins are between 35 and 40 kilodaltons.

Features: A zinc finger domain at the N-terminus and a direct repeat in a proteolytically stable C-terminal domain.

Interactions: Binds directly to TBP, recruits RNA polymerase II, in part through an interaction with the small subunit of TFIIF. Several acidic activators can bind TFIIB in vitro.

Functions: Stabilizes TBP binding to TATA element. Required for association of RNA polymerase II to the initiation complex. May be a target for regulatory transcription factors.

The structure of the TFIIB repeats bound to the TBP-TATA complex:

Three views: Front, Side, and Top.

TATA-Binding Protein is shown in green, TFIIB in red.

Search Entrez MEDLINE for TFIIB references.

Search GenBank for TFIIB sequences.

Additional search terms can be typed into the boxes.

Enter your query in the boxes below. A document matches a box if all words within it appear in one field of the document. The documents matching a box are combined with boxes following it using the selected operator to its right. The AND and BUT NOT operators limit retrieval and the OR operator expands it.

Checking the "fr" (Field Restriction) box limits the match to the fields checked in the table below.

fr and or but not
fr and or but not
fr and or but not
fr
Return up to documents.**
** Additional documents can be retrieved using the (More) button from the document list. **

Select Database: GenBank GenBank Updates Both
Field Restriction: (Applied only on query lines where "(fr)" is checked)
Locus Definition Accession No. NID Keywords
Source Reference Comment Features

Rev. 06/27/96

Return to Basal Transcription Factors Page.