TFIIH

Composition: Mammalian and yeast TFIIHs have at least six subunits. Most subunits are now cloned, although not all are published.

Yeast subunits: SSL2(RAD25), RAD3, SSL1, TFB1, TFB2, TFB3, TFB4.

In addition to the TFIIH subunits, there is an associated complex consisting of a CDC-like kinase and cyclin-like subunit. This kinase complex is sometimes referred to as TFIIK. Yeast subunits: KIN28 and CCL1.

Features: The two largest TFIIH subunits are ATP-dependent helicases of opposite polarity. Two of the smaller subunits have possible zinc finger domains.

Interactions: TFIIH appears to be dependent upon TFIIE for incorporation into the initiation complex. The associated kinase (TFIIK) complex can phosphorylate the C-terminal domain of the pol II largest subunit.

Functions: TFIIH is essential for promoter melting (separation of the two DNA strands) and/or promoter clearance (i.e. for pol II to break free of the initiation complex into elongation mode). Surprisingly, TFIIH also is essential for Nucleotide Excision Repair (NER) of damaged DNA. The relationship between TFIIH's transcription and repair functions is not understood yet.

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Rev. 06/27/96

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Copyright Steve Buratowski